2023
da Silva TF, Glória RA, de Sousa TJ, Americo MF, Freitas ADS, Viana MVC, de Jesus LCL, da Silva Prado LC, Daniel N, Ménard O, Cochet MF, Dupont D, Jardin J, Borges AD, Fernandes SOA, Cardoso VN, Brenig B, Ferreira E, Profeta R, Aburjaile FF, de Carvalho RDO, Langella P, Le Loir Y, Cherbuy C, Jan G, Azevedo V, Guédon É. 2023. Comprehensive probiogenomics analysis of the commensal Escherichia coli CEC15 as a potential probiotic strain. BMC Microbiol. 23(1):364.
doi: 10.1186/s12866-023-03112-4
Lima A, Carolina Barbosa Caetano A, Hurtado Castillo R, Gonçalves Dos Santos R, Lucas Neres Rodrigues D, de Jesus Sousa T, Kato RB, Vinicius Canário Viana M, Cybelle Pinto Gomide A, Figueira Aburjaile F, Tiwari S, Jaiswal A, Gala-García A, Seyffert N, Luiz de Paula Castro T, Brenig B, Matiuzzi da Costa M, Maria Seles Dorneles E, Le Loir Y, Azevedo V. 2023. Comparative genomic analysis of ovine and other host associated isolates of Staphylococcus aureus exhibit the important role of mobile genetic elements and virulence factors in host adaptation. Gene. 855:147131.
doi: 10.1016/j.gene.2022.147131
Américo MF, Freitas ADS, da Silva TF, de Jesus LCL, Barroso FAL, Campos GM, Santos RCV, Gomes GC, Assis R, Ferreira Ê, Mancha-Agresti P, Laguna JG, Chatel JM, Carvalho RDO, Azevedo V. 2023. Growth differentiation factor 11 delivered by dairy Lactococcus lactis strains modulates inflammation and prevents mucosal damage in a mice model of intestinal mucositis. Front Microbiol. 14:1157544.
doi: 10.3389/fmicb.2023.1157544
Rodrigo Dias de Oliveira Carvalho, Houem Rabath, Fillipe Luiz Rosa do Carmo, Juan Carlos Ariute, Flávia Figueira Aburjaile, Bertram Brenig, Yves Le Loir, Gwénaël Jan and Vasco Azevedo. 2023. Functional Swiss-type experimental cheeses diet promotes beneficial effects in mice gut microbiome during homeostasis and inflammation. Food Bioscience. 56: 103327.
https://doi.org/10.1016/j.fbio.2023.103327
Marine Mantel, Tales Fernando da Silva, Rafael Gloria, Danièle Vassaux, Kátia Duarte Vital, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes, Eric Guedon, Yves Le Loir, Ana Maria Caetano Faria, Malvyne Rolli-Derkinderen, Vasco Azevedo, Gwenael Jan. 2023. Fat matters: Fermented whole milk potentiates the anti-colitis effect of Propionibacterium freudenreichii. Journal of Functional Foods, 106,105614.
doi: 10.1016/j.jff.2023.105614
de Rezende Rodovalho, Vinícius; da Luz, Brenda Silva; Nicolas, Aurélie; Jardin, Julien; Briard-Bion, Valérie; Folador, Edson Luiz; Rodrigues dos Santos, Anderson; Jan, Gwénaël; Le Loir, Yves; Azevedo, Vasco; Guédon, Eric. 2023. Different culture media and purification methods unveil the core proteome of Propionibacterium freudenreichii-derived extracellular vesicles. microLife, 4: 1–15.
DOI: 10.1093/femsml/uqad029
2022
Noguès EB, Kropp C, Bétemps L, de Sousa C, Chain F, Auger S, Azevedo V, Langella P, Chatel JM. 2022. Lactococcus lactis engineered to deliver hCAP18 cDNA alleviates DNBS-induced colitis in C57BL/6 mice by promoting IL17A and IL10 cytokine expression. Sci Rep. 12(1):15641.
doi: 10.1038/s41598-022-19455-3
Carvalho RDO, Guédon E, Aburjaile FF, Azevedo V. 2022. Editorial: Probiogenomics of classic and next-generation probiotics. Front Microbiol. 13:982642.
doi: 10.3389/fmicb.2022.982642
Lima A., A.C. Barbosa Caetano, R. Hurtado Castillo, R. Gonçalves Dos Santos, D.L. Neres Rodrigues, T. de Jesus Sousa, R. Bentes Kato, M.V. Canário Viana, A.C. Pinto Gomide, F. Figueira Aburjaile, S. Tiwari, A. Jaiswal, A. Gala-García, N. Seyffert, T.L. de Paula Castro, B. Brenig, M. Matiuzzi da Costa, E.M. Seles Dorneles, Y. Le Loir, V. Azevedo. 2022. Comparative genomic analysis of ovine and other host associated isolates of Staphylococcus aureus exhibit the important role of mobile genetic elements and virulence factors in host adaptation. Gene. 147131.
doi: 10.1016/j.gene.2022.147131
da Luz BSR, de Rezende Rodovalho V, Nicolas A, Chabelskaya S, Jardin J, Briard-Bion V, Le Loir Y, de Carvalho Azevedo VA, Guédon É. 2022. Impact of Environmental Conditions on the Protein Content of Staphylococcus aureus and Its Derived Extracellular Vesicles. Microorganisms. 2022 Sep 9;10(9):1808.
doi: 10.3390/microorganisms10091808
Nicolas A, Deplanche M, Commere PH, Diot A, Genthon C, Marques da Silva W, Azevedo V, Germon P, Jamme H, Guédon E, Le Loir Y, Laurent F, Bierne H, Berkova N. 2022
Transcriptome Architecture of Osteoblastic Cells Infected With Staphylococcus aureus Reveals Strong Inflammatory Responses and Signatures of Metabolic and Epigenetic Dysregulation.
Front Cell Infect Microbiol. 12:854242.
doi: 10.3389/fcimb.2022.854242
Auger S, Kropp C, Borras-Nogues E, Chanput W, Andre-Leroux G, Gitton-Quent O, Benevides L, Breyner N, Azevedo V, Langella P, Chatel JM.
Intraspecific Diversity of Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii.
Int J Mol Sci. 2022 Feb 1;23(3):1705.
doi: 10.3390/ijms23031705.
Maioli TU, Borras-Nogues E, Torres L, Barbosa SC, Martins VD, Langella P, Azevedo VA, Chatel JM.
Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders.
Front Pharmacol. 2021 Dec 2;12:740636.
doi: 10.3389/fphar.2021.740636.
Belo GA, Cordeiro BF, Oliveira ER, Braga MP, da Silva SH, Costa BG, Martins FDS, Jan G, Le Loir Y, Gala-García A, Ferreira E, Azevedo V, do Carmo FLR. 2021. SlpB Protein Enhances the Probiotic Potential of L. lactis NCDO 2118 in Colitis Mice Model. Front Pharmacol. 12:755825.
doi: 10.3389/fphar.2021.755825.
Savassi B, Cordeiro BF, Silva SH, Oliveira ER, Belo G, Figueiroa AG, Alves Queiroz MI, Faria AMC, Alves J, da Silva TF, Campos GM, Esmerino EA, Rocha RS, Freitas MQ, Silva MC, Cruz AG, Vital KD, Fernandes SOA, Cardoso VN, Acurcio LB, Jan G, Le Loir Y, Gala-Garcia A, do Carmo FLR, Azevedo V. 2021. Lyophilized Symbiotic Mitigates Mucositis Induced by 5-Fluorouracil. Front Pharmacol. 12:755871.
doi: 10.3389/fphar.2021.755871
2021
Brenda Silva Rosa da Luz, Aurélie Nicolas, Svetlana Chabelskaya, Vinícius De Rezende Rodovalho, Yves Le Loir, Vasco Ariston De Carvalho Azevedo, Brice Felden, Eric Guédon. 2021. Environmental plasticity of the RNA content of Staphylococcus aureus extracellular vesicles. Frontiers in Microbiology. 12:634226.
doi: 10.3389/fmicb.2021.634226
Bárbara Fernandes Cordeiro, Juliana Lima Alves, Giovanna A Belo, Emiliano Rosa Oliveira, Marina P Braga, Sara Heloisa Silva, Luisa Lemos Santos, Jonas T Guimarães, Ramon Silva, Ramon S Rocha, Gwénaël Jan, Yves Le Loir, Marcia Cristina Silva, Mônica Q Freitas, Erick A Esmerino, Alfonso Gala-García, Enio Ferreira, Ana Maria Caetano Faria, Adriano G Cruz, Vasco Ariston De Carvalho Azevedo, Fillipe Luiz Rosa do Carmo. 2021. Therapeutic effects of probiotic Minas Frescal cheese on the attenuation of ulcerative colitis in a murine model. Front. Microbiol. 12:623920. https://doi.org/10.3389/fmicb.2021.623920
2020
Rezende Rodovalho V, da Luz BSR, Nicolas A, do Carmo FLR, Jardin J, Briard-Bion V, Jan G, Le Loir Y, de Carvalho Azevedo VA, Guedon E. 2020. Environmental conditions modulate the protein content and immunomodulatory activity of extracellular vesicles produced by the probiotic Propionibacterium freudenreichii. Appl Environ Microbiol. 2020 Dec 11:AEM.02263-20.
doi: 10.1128/AEM.02263-20.
Rabah H, do Carmo FLR, Carvalho RDO, Cordeiro BF, da Silva SH, Oliveira ER, Lemos L, Cara DC, Faria AMC, Garric G, Harel-Oger M, Le Loir Y, Azevedo V, Bouguen G, Jan G. 2020.Beneficial Propionibacteria within a Probiotic Emmental Cheese: Impact on Dextran Sodium Sulphate-Induced Colitis in Mice. Microorganisms. 2020 Mar 7;8(3):380.
doi: 10.3390/microorganisms8030380.
Castro-Oliveira L., Silva M.O., Carvalho R.D.O., Anchiêta A., Benevides L.J., Oliveira C.J.F., Jan G., Figueiredo H.C.P., Azevedo V.A.C. and Soares S.C.. 2020. Omics of probiotic bacteria: which features to seek? Genet. Mol. Res. 19(2): GMR18599
doi: 10.4238/gmr18599
Leite, EL; de Oliveira, AF; Do Carmo, FLR; Berkova, N; Barh, D; Ghosh, P; Azevedo, V. 2020 Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus. Anais da Academia Brasileira de Ciências Volume: 92 Issue: suppl 2 Pages: e20201216 Article Number: e20201216
Vinícius de Rezende Rodovalho, Brenda Silva Rosa da Luz, Houem Rabah, Fillipe Luiz Rosa do Carmo, Edson Luiz Folador, Aurélie Nicolas, Julien Jardin, Valérie Briard-Bion, Hervé Blottière, Nicolas Lapaque, Gwenaël Jan, Yves Le Loir, Vasco Ariston De Carvalho Azevedo, Eric Guédon. 2020. Extracellular vesicles produced by the probiotic Propionibacterium freudenreichii CIRM-BIA 129 mitigate inflammation by modulating the NF-κB pathway. Front Microbiol. 11:1544.
doi: 10.3389/fmicb.2020.01544. eCollection 2020.
Tartaglia, Natayme Rocha; Nicolas, Aurelie; Rodovalho, Vinicius de Rezende; Luz, Brenda Silva Rosa da; Briard-Bion, Valerie; Krupova, Zuzana; Thierry, Anne; Coste, Francois; Burel, Agnes; Martin, Patrice; Jardin, Julien; Azevedo, Vasco; Le Loir, Yves; Guedon, Eric. 2020 Extracellular vesicles produced by human and animal Staphylococcus aureus strains share a highly conserved core proteome. Scientific reports 10(1): 8467.
doi:10.1038/s41598-020-64952-y
Elma Lima Leite, Arthur Gautron, Martine Deplanche, Aurelie Nicolas, David Gilot, Vasco Azevedo, Petr Broz, Yves Le Loir, Nadia Berkova. 2020. Inflammasomes involvement in Staphylococcus aureus infection of human osteoblast-like cells. Cellular Microbiology 16:e13204.
doi: 10.1111/cmi.13204.
Houem Rabah, Fillipe Luiz Rosa do Carmo, Rodrigo Dias de Oliveira Carvalho, Barbara Fernandes Cordeiro,Sara Heloisa da Silva, Emiliano Rosa Oliveira, Luisa Lemos, Denise Carmona Cara, Ana Maria Caetano Faria, Gilles Garric, Marielle Harel-Oger, Yves Le Loir, Vasco Azevedo, Guillaume Bouguen, and Gwénaël Jan. 2020. Effect of probiotic Emmental cheese on DSS-induced colitis in mice and in a clinical pilot study. Microorganisms. 8(3):380.
doi: 10.3390/microorganisms8030380.8467
2019
Imanishi I., A. Nicolas, A.-C. Barbosa Caetano, T. L. de Paula Castro, N. Rocha Tartaglia, R. Mariutti, E. Guédon, S. Even, N. Berkova, R. K. Arni, N. Seyffert, V. Azevedo, K. Nishifuji and Y. Le Loir. 2019. Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activity. Scientific Reports. 9:16336
https://doi.org/10.1038/s41598-019-52777-3 (limited access).
Breyner NM, Boas PBV, Fernandes G, de Carvalho RD, Rochat T, Michel ML, Chain F, Sokol H, de Azevedo M, Myioshi A, Azevedo VA, Langella P, Bermúdez-Humarán LG, Chatel JM. Oral delivery of Pancreatitis-Associated Protein by Lactococcus lactis displays protective effects in DNBS-induced colitis model and is able to modulate the composition of the microbiota. Environ Microbiol. 2019 Jul 19.
doi: 10.1111/1462-2920.14748.
Rosa do Carmo, F. L., Rabah H., Fernandes Cordeiro, B., da Silva, S. H., Miranda Pessoa, R., Antunes Fernandes, S. O., Nascimento Cardoso, V., Gagnaire, V., Deplanche, M., Savassi, B., Figueiroa, A., Rosa Oliveira, E., Fonseca, C. C., Alves Queiroz, M. I., Morais Rodrigues, N., de Cicco Sandes, S. H., Cantini Nunes, Á., Lemos, L., de Lima Alves, J., Caetano Faria, A. M., Ferreira, Ê., Le Loir, Y., Jan, G., Azevedo, V. 2019. Probiotic Propionibacterium freudenreichii requires SlpB protein to mitigate mucositis induced by chemotherapy. Oncotarget. 10(68):7198-7219.
doi: 10.18632/oncotarget.27319.
Flávia Figueira Aburjaile, Gwénaël Jan, Yves Le Loir, Vasco Azevedo and Rodrigo Dias de Oliveira Carvalho. 2019. Wild-Type and Genetically Improved Strains of Dairy Origin Probiotic as Potential Treatments for Intestinal Mucositis. Journal of Pharmacy and Pharmacology 7:177-186. doi: 10.17265/2328-2150/2019.04.004
Vasco Azevedo, Jean-Marc Chatel, Philippe Langella et Yves Le Loir, « Le laboratoire international associé Bact-Inflam, l’aboutissement de 17 années de collaboration France-Brésil », Histoire de la recherche contemporaine [En ligne], Tome VII N°2 | 2018, mis en ligne le 15 avril 2019. URL : http://journals.openedition.org/hrc/2490 ;
doi: 10.4000/hrc.2490.
2018
Carvalho R, Vaz A, Pereira FL, Dorella F, Aguiar E, Chatel JM, Bermudez L, Langella P, Fernandes G, Figueiredo H, Goes-Neto A, Azevedo V. Gut microbiome modulation during treatment of mucositis with the dairy bacterium Lactococcus lactis and recombinant strain secreting human antimicrobial PAP. Sci Rep. 2018 Oct 10;8(1):15072.
doi: 10.1038/s41598-018-33469-w.
B.F. Cordeiro, E.R. Oliveira, S.H. Silva, B.M. Assis, L.B. Acurcio, L.L. Santos, J. L. Alves, H.C. Assis, A. T. Vieira, A.M. Caetano Faria, E. Ferreira, Y. Le Loir, G. Jan, L. R. Goulart, V.A. Azevedo, R.D.D.O. Carvalho, F.L.R. Do Carmo. 2018. Whey protein isolate-supplemented beverage fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138 in the prevention of mucositis in mice. Front. Microbiol. 9:2035.
doi: 10.3389/fmicb.2018.02035.
F.L. R. Do Carmo, W. Marques Silva, G. Campos Tavares, I. Coimbra Ibraim, B. Fernandes Cordeiro, E. Rosa Oliveira, H. Rabah, C. Cauty, S.H. Silva, M. Canário, A.C. Barbosa Caetano, R. Gonçalves Santos, R. Dias De Oliveira Carvalho, J. Jardin, F.L. Pereira, E.L. Folador, Y. Le Loir, H.C. Pereira Figueiredo, G. Jan, V. A. Azevedo. 2018. Mutation of the surface layer protein SlpB has pleiotropic effects in the probiotic Propionibacterium freudenreichii 129. Front Microbiol. 9:1807.
doi: 10.3389/fmicb.2018.01807.
N.R. Tartaglia, K. Breyne, C. Cauty, J. Jardin, D. Chrétien; K. Demeyere, N. Berkova, V. Azevedo, E. Meyer, E. Guedon, Y. Le Loir. 2018. Staphylococcus aureus extracellular vesicles elicit an immunostimulatory response in experimental mouse of mastitis. Front Cell Infect Microbiol. 8:277.
doi: 10.3389/fcimb.2018.00277.ol.
R. F. S. Souza, L. Rault, N. Seyffert, V. Azevedo, Y. Le Loir and S. Even. 2018. Lactobacillus casei BL23 modulates the innate immune response in Staphylococcus aureus-stimulated bovine mammary epithelial cells. Beneficial Microbes. 25:1-12.
doi: 10.3920/BM2018.0010.
Fillipe Luiz R. Carmo, Houem Rabah, Rodrigo De Oliveira Carvalho, Floriane Gaucher, Bárbara F.Cordeiro, Sara H. da Silva, Yves Le Loir, Vasco A. Azevedo, and Gwénaël Jan. 2018. Bacterial extractable surface proteins in probiotic / host interaction. Front. Microbiol. 9:645.
doi: 10.3389/fmicb.2018.00645.
Declaration of invention and of valorizable results (patenting process ongoing)
Patent: NEW TREATMENT AGAINST MUCOSITIS. international patent application, filed on 04/09/2019, under priority of the French application FR1870991, was registered by the EPO under the number: PCT / EP2019 / 073626. Inventors: Dr Gwénaël Jan, Dr Yves Le Loir, Dr Fillipe Luiz Rosa do Carmo, Pr Vasco Azevedo, Dr Rodrigo Dias de Oliveira Carvalho, Dr Barbara Fernandes Cordeiro, Dr Florence Valence.
Do Carmo F., Azevedo V., Le Loir Y., De Oliveira Carvalho R.D., Cordeiro B.F., Valence F., Jan G. 2018. Milk fermented by the probiotic Propionibacterium freudenreichii preventively attenuates chemotherapy-induced mucositis in a murine model.
